Global study on male infertility to advance development of new non-hormonal female contraceptives

The international research team will address this gap by developing and validating novel sperm assessments, and systematically examining the function of sperm from 1,000 fertile men who have naturally fathered children. In comparison, they will investigate the sperm of 1,000 men with unexplained infertility to identify differences in functional sperm parameters between fertile and infertile individuals which can then be used to test new concepts for female contraceptives.

Dr Meurig Gallagher, School of Medical Sciences, University of Birmingham who is part of the research team said:

“A key new observation of sperm will be the detailed analysis of their tail beat using a new analytics software, ‘FAST’, developed in Birmingham. These tail beat patterns act like a “fitness test” of sperm capability.”

Professor Timo Strünker from the Centre of Reproductive Medicine and Andrology (CeRA) of the University of Münster said:

“We are confident that the insights gained from this study will have the added benefit of significantly improving early diagnostics of male infertility and clinical care for affected couples.”

Unexplained male infertility

In about a third of infertile men, semen parameters remain within normal ranges. This condition, known as unexplained male infertility, involves functional defects of the sperm that cannot be detected through traditional semen analysis.

This will be the first time a direct comparison is made between fertile and infertile males with the most modern sperm-assessment tools at this scale. Participants will be recruited from all three countries, and the diversity provided across these populations should help ensure that results are widely applicable.

In Birmingham patient and donor recruitment will be done through Birmingham Women’s Hospital, who partner with the University of Birmingham through the Centre for Human Reproductive Science. The Centre for Human Reproductive Science brings together the basic, translational and clinical science research in human reproduction performed across the organisations.

Understanding the functional differences in sperm from fertile and infertile men shall inform drug discovery programs aimed at developing small molecules that specifically target sperm in the female reproductive tract, preventing the sperm from fertilizing the egg. Advancing such innovative, female-controlled, non-hormonal contraceptives is an important global concern.

The study has just begun and is expected to conclude within two years. It will be coordinated by Prof. Timo Strünker, Prof. Sabine Kliesch, Dr. Christoph Brenker (CeRA), and Prof. Frank Tüttelmann (Centre of Medical Genetics) at the University Hospital and University of Münster, the primary recipient of the funding award.

It is conducted in collaboration with Dr. Sarah Martins da Silva, Dr Zoe Johnston and Prof. Christopher Barratt from Ninewells Hospital and Medical School at the University of Dundee, as well as Professor Jackson Kirkman-Brown (Centre for Human Reproductive Science) and Dr Meurig Gallagher (Metabolism and Systems Science) at the University of Birmingham.